Biopharmaca BiofarmakaSynergistic Anticandidal Activity of Xanthorrhizol in Combination with Ketoconazole or Amphotericin B
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JOURNAL 2009
Synergistic Anticandidal Activity of Xanthorrhizol in Combination with Ketoconazole or Amphotericin B

Please use this identifier to cite or link to this item
http://biofarmaka.ipb.ac.id/publication/journal/143-synergistic-anticandidal-activity-of-xanthorrhizol-in-combination-with-ketoconazole-or-amphotericin-b
Title
 
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Synergistic Anticandidal Activity of Xanthorrhizol in Combination with Ketoconazole or Amphotericin B

Authors
 
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Yaya Rukayadi1,2, Kwanhyoung Lee3, Myoung-su Lee1, Dongeun Yong4 & Jae-Kwan Hwang1,3
Corporates





 
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1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea
2Biopharmaca Research Center and Research Center for Biotechnology and Bioresources, Bogor Agricultural University, Bogor, Indonesia;
3Department of Biomaterials and Engineering, Yonsei University, Seoul, Korea; and
4Department of Laboratory Medicine, Research Institute of Bacterial Resistance, College of Medicine, Yonsei University, Seoul, Korea

Issue Date : December 2009
Publisher

 
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FEMS Yeast Res
© 2009 Federation of European Microbiological Societies
Published by Blackwell Publishing Ltd. All rights reserved.
Series / Report No :
 

 
Physical Description :
 
2009, Vol. 9 No. 8 p 1302–1311
 
Language : en
Abstract











 
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Candida species are responsible for the fourth most common nosocominal bloodstream infection. Xanthorrhizol, a sesquiterpene compound isolated from Curcuma xanthorrhiza Roxb. has been reported to have anticandidal activity. The aim of this study is to investigate the synergistic anticandidal effect of xanthorrhizol in combination with ketoconazole or amphotericin B against Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis, and Candida tropicalis. Mostly, xanthorrhizol in combination with ketoconazole or amphotericin B exhibited the synergistic anticandidal effects against all species of Candida tested. In combination with xanthorrhizol, the concentration of ketoconazole or amphotericin B for inhibiting the growth of the tested Candida species could be reduced by Z50%. Time–kill curves showed that 1/2 minimum inhibitory concentration (MIC) dose of xanthorrhizol, amphotericin B, or ketoconazole alone against each of the six Candida species did not inhibit the growth of all Candida species tested. However, 1/2 MIC dose of xanthorrhizol in combination with 1/2 MIC dose of ketoconazole or 1/2 MIC dose of amphotericin B exhibited growth inhibition of all Candida species tested and reduced viable cells by several logs within 4 h. These results support the potential use of xanthorrhizol as an anticandidal agent, and it can be used complementarily with other conventional antifungal agents.

Source url
 
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http://biofarmaka.ipb.ac.id/publication/journal/143-synergistic-anticandidal-activity-of-xanthorrhizol-in-combination-with-ketoconazole-or-amphotericin-b

Mesh :

 

Keywords : anticandidal; amphotericin B; ketoconazole; synergistic; xanthorrhizol
How to cite this article
 
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Rukayadi, Y., KY Lee, MS Lee, D. Yong & JK Hwang. 2009. Synergistic Anticandidal Activity of Xanthorrhizol in Combination with Ketoconazole or Amphotericin B. FEMS Yeast Res, 9(8): 1302–1311
url: http://biofarmaka.ipb.ac.id/publication/journal/143-synergistic-anticandidal-activity-of-xanthorrhizol-in-combination-with-ketoconazole-or-amphotericin-b

 

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