Biopharmaca BiofarmakaTNF-α Production Inhibitory Activity, Phenolic, Flavonoid and Tannin Contents of Selected Indonesian Medicinal Plants

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TNF-α Production Inhibitory Activity, Phenolic, Flavonoid and Tannin Contents of Selected Indonesian Medicinal Plants

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http://biofarmaka.ipb.ac.id/publication/journal/628-tnf-production-inhibitory-activity-phenolic-flavonoid-and-tannin-contents-of-selected-indonesian-medicinal-plants
Title
 
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TNF-α Production Inhibitory Activity, Phenolic, Flavonoid and Tannin Contents of Selected Indonesian Medicinal Plants

Authors

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I. Batubara1,2,*, S. Kotsuka3, K. Yamauchi3, H. Kuspradini4, T. Mitsunaga3 and L.K. Darusman1,2
Corporate







 
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1Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, IPB Darmaga Campus, Bogor, Indonesia
2Biopharmaca Research Center, Bogor Agricultural University, Jl Taman Kencana No. 3 Bogor 16128, Indonesia
3Faculty of Applied Biological Science, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan
4Faculty of Forestry, Mulawarman University, Samarinda, East Kalimantan, Indonesia
*Coressponding Author: I. Batubara, Biopharmaca Research Center, Bogor Agricultural University, Jl. Taman Kencana No. 3, Bogor 16128. Telp +62-251-8373561 Fax +62+251+8347525 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Issue Date : March 15, 2012
Publisher : Research Journal of Medicinal Plant
Series / Report No :
 
ISSN 1819-3455 / DOI: 10.3923/rjmp.2012.406.415
 
Physical Description :
 
2012, Volume: 6, Issue: 6, Page No: 406-415
 
Language : en
Abstract













 
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In this study 28 Indonesian medicinal plants species has been screened as potential Tumor Necrosis Factor (TNF)-α inhibitor. Plant materials were extracted with methanol. The activity test was performed on human monocyte-derived THP-1 (ATCC No. TIB 202) which was stimulated by Lipopolyssacharide (LPS). The TNF-α production and cell viability were determined by commercial ELISA kit and WST-1, respectively. All extracts were determined for their phenolic, flavonoid and tannin contents by spectrophotometry and chromatography methods. From 40 plant materials, 5 plant materials had cell viability lower than 70% at 10 ppm concentration and about 8 plant materials had good cell viability higher than 90% at 10 ppm concentration. Among 8 plant materials extract which had good cell viability, only Avicenia sp. stem and Goniothalamus macrophyllus leaf methanol extracts had high TNF-α inhibitory activity. The total phenolic, flavonoid and tannin contents were varied depending on the sample. No correlation was found between TNF-α inhibitory activity with the total phenolic content, flavonoid content and tannin content. In conclusion, among Indonesian medicinal plants, the highest potential as TNF-α inhibitors were Avicenia sp. stem and G. macrophyllus leaves.
Source url
 
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http://biofarmaka.ipb.ac.id/publication/journal/628-tnf-production-inhibitory-activity-phenolic-flavonoid-and-tannin-contents-of-selected-indonesian-medicinal-plants

Mesh :

 

Keywords  Indonesian medicinal plants, TNF-α inhibitor, inflammation, phenolic, flavonoid, tannin
How to cite this article

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I. Batubara, S. Kotsuka, K. Yamauchi, H. Kuspradini, T. Mitsunaga and L.K. Darusman, 2012. TNF-α Production Inhibitory Activity, Phenolic, Flavonoid and Tannin Contents of Selected Indonesian Medicinal Plants. Research Journal of Medicinal Plant, 6: 406-415
url: http://scialert.net/abstract/?doi=rjmp.2012.406.415
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