Biopharmaca BiofarmakaDissolution of Curcumin Microencapsulation Coated by Chitosan-Alginate-Glutaraldehide
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JOURNAL 2010
Dissolution of Curcumin Microencapsulation Coated by Chitosan-Alginate-Glutaraldehide

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http://biofarmaka.ipb.ac.id/publication/journal/64-dissolution-of-curcumin-microencapsulation-coated-by-chitosan-alginate-glutaraldehide
Title 

Disolusi Mikroenkapsulasi Kurkumin Tersalut Gel Kitosan-Alginat-Glutarldehida

Authors
Herdini1,2*, Latifah K. Darusman2,3, & Purwantiningsih Sugita2
Corporate



 
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1Program Studi Farmasi, FMIPA, ISTN, Jakarta 12620, Indonesia
*Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
2Departemen Kimia, FMIPA, IPB, Bogor 16680, Indonesia
3Pusat Studi Biofarmaka LPPM-IPB, Kampus IPB Taman Kencana, Jl. Taman Kencana No. 3, Bogor 16128

Issue Date : 2010
Publisher : Makara Seri Sains
Series / Report No :
 
ISSN: 1693-6671
 
Physical Description :
 
2010 Vol. 14 No. 1, p 57-62
 
Language : id
Abstract












 
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In vitro dissolution of curcumin coated by chitosan-alginate gel in its optimum condition was studied. The maceration process using 17.08% ethanol yields and the content of the curcumin in the extract detected by visible spectrophotometry λ 430 nm is found to be 10.30 %. Its optimum condition was obtained using response surface method at concentrations ratio of alginate 0.62% (b/v) and glutaraldehide 4.63% (v/v), respectively, where the chitosan concentration was fixed (1.75% [b/v]). The dissolution assay was done at 37 0C, at 100 rpm of stirring rate in 8 hours. Aliquots were taken at 15, 30, 45, 60, 90, 120, 150, 180, 240, 300, 360, 420, 480 minutes. Absorbance of the Aliquots was measured at λ 430 nm. The curcumin released has the best linear correlation to the first order reaction with released constant, k = 2.24 10-3 minute-1 while it’s half live is t1/2 = 5.16 hours. Release curcumin was determined mainly by diffusion mechanism. Compared to the result based on Fick model, the one of Higuchi model is better in agreement in reproducing the released data.
Source url
 
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http://biofarmaka.ipb.ac.id/publication/journal/64-dissolution-of-curcumin-microencapsulation-coated-by-chitosan-alginate-glutaraldehide

Mesh :

 

Keywords : chitosan-alginate-glutaraldehide, curcumin, diffusion-dissolution, microencapsulation
How to cite this article
 
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Herdini, L.K. Darusman, & P. Sugita. 2010. Dissolution of Curcumin Microencapsulation Coated by Chitosan-Alginate-Glutaraldehide. Makara Seri Sains, 14(1): 57-62.
url: http://biofarmaka.ipb.ac.id/publication/journal/64-dissolution-of-curcumin-microencapsulation-coated-by-chitosan-alginate-glutaraldehide
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