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| Please use this identifier to cite or link to this item http://biofarmaka.ipb.ac.id/publication/journal/107-inhibisi-lipase-pankreas-secara-in-vitro-oleh-ekstrak-air-dan-etanol-daun-asam-jawa-tamarindus-indica-dan-rimpang-kunci-pepet-kaempferiae-rotundae |
| Title |
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Inhibisi Lipase Pankreas secara In Vitro oleh Ekstrak Air dan Etanol Daun Asam Jawa (Tamarindus indica) dan Rimpang Kunci Pepet (Kaempferiae rotundae) |
| Authors |
: | Dyah Iswantini Pradono1,2,3*, Latifah Kosim Darusman1,2,3 & Ai Susanti2 |
| Corporates |
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1Jurusan Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Jalan Raya Pajajaran, Bogor 16144 |
| Issue Date | : | February 2011 |
| Publisher | : | Jurnal Natur Indonesia |
| Series / Report No | : |
ISSN: 1410-9379 |
| Physical Description | : |
2011 Vol. 13 No. 2, p 146-154 |
| Language | : | en |
| Abstract |
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Tamarind and kunci pepet has been used traditionally as herbal medicine to reduce body weight or used as antiobesity. But the mechanism in vitro of this herbal in reducing body weight has not been known yet. The objective of this research is to evaluate these herbal as antiobesity by their water and ethanol extracts capability in inhibiting pancreatic lipase activity in vitro at pH 8, incubation time 45 minutes, and temperature 400C. Pancreatic lipase used in this research was human pancreatic lipase with concentration of 1.4 × 10-5 μg/μl and the substrate was sesame oil with concentration of 16.2 μg/μl. The water and ethanol extracts of tamarind leaves contained alkaloids, flavonoids, saponins, steroids, and tannins. Water extract of kunci pepet contained alkaloids, flavonoids, saponins, and tannins, while ethanol extract contained alkaloids, flavonoids, saponins, and triterpenoids. The results of tamarind leaves extracts showed that ethanol extract in concentration of 150 ppm had the highest inhibitory effect, with the value of 49.0%. Water extract of kunci pepet at concentration of 200 ppm had the highest inhibition, with the value of 65.1%. These values were higher than inhibitory effect of Xenical® 100 ppm as the positive control, with the inhibition value of 10.6%. |
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| Keywords |
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antiobesity, asam jawa (Tamarindus indica), inhibition, in vitro pancreatic lipase activity, kunci pepet (Kaempferiae rotunda) |
| How to cite this article |
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Iswantini, D., L.K. Darusman, & A. Susanti. 2011. Inhibisi Lipase Pankreas secara In Vitro oleh Ekstrak Air dan Etanol Daun Asam Jawa (Tamarindus indica) dan Rimpang Kunci Pepet (Kaempferiae rotundae). Jurnal Natur Indonesia, 13(2): 146-154. url: http://biofarmaka.ipb.ac.id/publication/journal/107-inhibisi-lipase-pankreas-secara-in-vitro-oleh-ekstrak-air-dan-etanol-daun-asam-jawa-tamarindus-indica-dan-rimpang-kunci-pepet-kaempferiae-rotundae |
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