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Brazilin Content, Antioxidative and Lipase Inhibition Effects of Sappanwood (Caesalpinia Sappan) from Indonesia

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JOURNAL 2010
Brazilin Content, Antioxidative and Lipase Inhibition Effects of Sappanwood (Caesalpinia Sappan) from Indonesia

Please use this identifier to cite or link to this item
http://biofarmaka.ipb.ac.id/publication/journal/144-brazilin-content-antioxidative-and-lipase-inhibition-effects-of-sappanwood-caesalpinia-sappan-from-indonesia
Title
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Brazilin Content, Antioxidative and Lipase Inhibition Effects of Sappanwood (Caesalpinia Sappan) from Indonesia
Authors
 		 :
 		 Irmanida Batubara1,2, Mohamad Rafi1,2, Siti Sa'diah2,3, M. Agung Zaim2, Susi Indariani2, Tohru Mitsunaga4
Corporates





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1Departement of Chemistry, Faculty of Mathematics & Natural Sciences, Bogor Agricultural University, Indonesia.
2Biopharmaca Research Center, Institute of Research & Community Services, Bogor Agricultural University, Indonesia.
3Department Anatomy, Physiology, Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia
4Department of Applied Science, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan
Issue Date : November 2010
Publisher  :  Journal of Chemistry and Chemical Engineering.
Series / Report No :
 		 ISSN: 1934-7375
 
Physical Description :
 		 2010, Vol. 4 No.10 p 50-55
 
Language : en
Abstract







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Determination of brazilin by High Performance Liquid Chromatography (HPLC) method and measurement of the antioxidative and lipase inhibition effects in the Caesalpinia sappan wood from various locations in Indonesia is described in this paper. Brazilin was separated from sample matrix using a reversed phase C18, Shim-pack VP column with the mobile phase in a gradient elution for 45 mm from 5% to 100% methanol in 0.05% aqueous trifluoroacetic acid. Brazilin in ethanolic extracts of C. sappan wood was in the range of 5.81 to 24.85 mg/g on dry-weight basis. Antioxidant and lipase inhibition activities expressed by IC50 values from all samples were in the range from 6.60 to 11.53 μg/mL and 50.76 to 203.21 μg/mL, respectively. Antioxidative and lipase inhibition potency of all ethanolic extracts were compared to vitamin C and chloramphenicol, isopropyl methyiphenol and tetracyclin, respectively.
Source url
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http://biofarmaka.ipb.ac.id/publication/journal/144-brazilin-content-antioxidative-and-lipase-inhibition-effects-of-sappanwood-caesalpinia-sappan-from-indonesia
Mesh :

 
Keywords
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 		 Caesalpinia sappan, sappanwood, brazilin, antioxidant activity, lipase inhibition activity, HPLC
How to cite this article
 		 :


 

Batubara, I., M. Rafi, S. Sa'diah, M.A. Zaim, S. Indariani & T.Mitsunaga. 2010. Brazilin Content, Antioxidative and Lipase Inhibition Effects of Sappanwood (Caesalpinia Sappan) from Indonesia. Journal of Chemistry and Chemical Engineering, 4(10): 50-55.
url: http://biofarmaka.ipb.ac.id/publication/journal/144-brazilin-content-antioxidative-and-lipase-inhibition-effects-of-sappanwood-caesalpinia-sappan-from-indonesia
   

 
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