Dissolution of Curcumin Microencapsulation Coated by Chitosan-Alginate-Glutaraldehide

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Disolusi Mikroenkapsulasi Kurkumin Tersalut Gel Kitosan-Alginat-Glutarldehida

Herdini1,2*, Latifah K. Darusman2,3, & Purwantiningsih Sugita2



1Program Studi Farmasi, FMIPA, ISTN, Jakarta 12620, Indonesia
*Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
2Departemen Kimia, FMIPA, IPB, Bogor 16680, Indonesia
3Pusat Studi Biofarmaka LPPM-IPB, Kampus IPB Taman Kencana, Jl. Taman Kencana No. 3, Bogor 16128

Issue Date : 2010
Publisher : Makara Seri Sains
Series / Report No :
ISSN: 1693-6671
Physical Description :
2010 Vol. 14 No. 1, p 57-62
Language : id


In vitro dissolution of curcumin coated by chitosan-alginate gel in its optimum condition was studied. The maceration process using 17.08% ethanol yields and the content of the curcumin in the extract detected by visible spectrophotometry λ 430 nm is found to be 10.30 %. Its optimum condition was obtained using response surface method at concentrations ratio of alginate 0.62% (b/v) and glutaraldehide 4.63% (v/v), respectively, where the chitosan concentration was fixed (1.75% [b/v]). The dissolution assay was done at 37 0C, at 100 rpm of stirring rate in 8 hours. Aliquots were taken at 15, 30, 45, 60, 90, 120, 150, 180, 240, 300, 360, 420, 480 minutes. Absorbance of the Aliquots was measured at λ 430 nm. The curcumin released has the best linear correlation to the first order reaction with released constant, k = 2.24 10-3 minute-1 while it’s half live is t1/2 = 5.16 hours. Release curcumin was determined mainly by diffusion mechanism. Compared to the result based on Fick model, the one of Higuchi model is better in agreement in reproducing the released data.
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Keywords : chitosan-alginate-glutaraldehide, curcumin, diffusion-dissolution, microencapsulation
How to cite this article

Herdini, L.K. Darusman, & P. Sugita. 2010. Dissolution of Curcumin Microencapsulation Coated by Chitosan-Alginate-Glutaraldehide. Makara Seri Sains, 14(1): 57-62.
url: http://biofarmaka.ipb.ac.id/publication/journal/64-dissolution-of-curcumin-microencapsulation-coated-by-chitosan-alginate-glutaraldehide
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